Publications

A metallomics approach to compare element speciation of healthy with cancer cells exposed in vitro to selenium at parts-per-billion levels

This poster relates to work carried out under project S1 – Novel selenium speciation methods and reference materials to support new food supplements and anti-cancer therapy of the NMS Chemical and Biological Metrology programme.

Chemotherapy drugs have been shown in vitro to be more effective in the presence of increased levels of selenium (Se). Whilst cancer cells are sensitised to chemotherapy by Se, healthy cells may be protected.

Identifying differences in intracellular and headspace element speciation between healthy and cancer cells exposed to Se drugs is essential to determine the optimum combination treatment and, therefore, to maximize any interaction observed. This poster describes a metallomics approach to compare element speciation of healthy cells with cancer cells exposed in vitro to selenium at parts-per-billion levels.

This poster was presented at the European Winter Conference on Plasma Spectrochemistry held in Graz, Austria in February 2009.

To download this poster click on the link below (you must be logged in). For further information about topics covered by the poster, please contact the NMS helpdesk at LGC.