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The Need for Standardization of Tacrolimus Assays
Owing to the lack of an internationally recognized tacrolimus reference material and reference method, current LC-MS and immunoassay test methods used to monitor tacrolimus concentrations in whole blood are not standardized. The aim of this study was to assess the need for tacrolimus assay standardization. Tacrolimus assay standardisation will be necessary to compare patient results between clinical laboratories. Improved assay accuracy is required to provide optimized drug dosing and consistent care across transplant centers globally.
Further information can be obtained from Clinical Chemistry or by contacting the authors via the NMS helpdesk at LGC.
- Author - Levine D, Maine G, Armbruster D, Mussell C, Buchholz C, O'Connor G, Tuck V, Johnston A and Holt D
- Reference Number - Clinical Chemistry December 2011 vol. 57 no. 12 1739-1747
Last modified on
21 March 2012.